Table 4.
Peak association regions in the SPL or MPL GWAS.
| SNP | Allele | p Value | OR (95% CI) | Chromosome | Region | Gene |
|---|---|---|---|---|---|---|
| rs12249496 | A | 9.9e−7 | 2.2 (1.6–3.0) | 10 | 130,670,196–130,686,938 | |
| rs17417060 | G | 1.2e−6 | 2.1 (1.6–2.9) | 10 | 45,412,777–45,446,791 | TMEM72 |
| kgp3442760 | A | 1.2e−6 | 1.9 (1.5–2.5) | 14 | 62,635,965–62,652,220 | TMEM72-AS1 |
| kgp5383559 | A | 2.8e−6 | 2.0 (1.5–2.8) | 4 | 53,586,179–53,739,262 | ERVMER34-1 LOC152578 |
| kgp11318955 | A | 4.5e−6 | 1.8 (1.4–2.3) |
RASL11B
SCFD2 |
||
| kgp4348860 | A | 3.5e−6 | 2.4 (1.7–3.6) | 22 | 28,149,693–28,150,815 | MN1 |
| rs870204 | A | 5.5e−6 | 2.0 (1.5–2.7) | 10 | 45,458,485 | RASSF4 |
| kgp2538268 | G | 5.6e−6 | 1.8 (1.4–2.3) | 6 | 19,078,368–19,128,940 | LOC101928519 |
GWAS, genome-wide association study; MPL, moderate prolonged lymphopenia; OR, odds ratio; SNP, single nucleotide polymorphism; SPL, severe prolonged lymphopenia.