Table 1.
Clinical and demographic characteristics of chronically HCV infected patients of the discovery cohort (N = 88), the French replication cohort (N = 161), and the Swiss replication cohort (N = 453).
| Covariate | Category | Discovery cohort | French replication cohort | Swiss replication cohort | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No fibrosis | Severe fibrosis | Total (%) | No fibrosis | Severe fibrosis | Total (%) | No fibrosis | Severe fibrosis | Total (%) | ||
| N = 40 | N = 48 | N = 88 | N = 102 | N = 59 | N = 161 | N = 148 | N = 308 | N = 456 | ||
| Sex | Female | 22 | 25 | 47 (53.4%) | 61 | 22 | 83 (51.5%) | 74 | 90 | 164 (36%) |
| METAVIR score | F0 | 13 | – | 13 (14.8%) | 15 | – | 15 (9.3%) | 39 | – | 39 (9%) |
| F1 | 27 | – | 27 (30.7%) | 87 | – | 87 (54.0%) | 106 | – | 106 (23%) | |
| F3 | – | 32 | 32 (36.3%) | – | 30 | 30 (18.6%) | – | 128 | 128 (28%) | |
| F4 | – | 16 | 16 (18.2%) | – | 29 | 29 (18.0%) | – | 180 | 180 (40%) | |
| Alcohol consumption (a) | Low | 40 | 42 | 82 (93.1%) | 91 | 40 | 131 (81.4%) | 65 | 126 | 191 (42%) |
| High | – | 7 | 7 (7.9%) | 11 | 19 | 30 (18.6%) | 80 | 181 | 261 (58%) | |
| HCV mode of acquisition | IDU | 9 | 16 | 25 (28.4%) | 39 | 21 | 60 (37.3%) | 54 | 101 | 155 (34%) |
| Blood transfusion | 22 | 23 | 45 (51.1%) | 41 | 29 | 70 (43.4%) | 35 | 60 | 95 (21%) | |
| Other/NA | 9 | 9 | 18 (20.5%) | 22 | 9 | 31 (19.3%) | 56 | 147 | 203 (45%) | |
| HCV genotype | 1 | 25 | 34 | 59 (67.0%) | 77 | 39 | 116 (72.0%) | 90 | 142 | 232 (51%) |
| 2 | 9 | 1 | 10 (11.4%) | 6 | 2 | 8 (5.0%) | 13 | 38 | 51 (11%) | |
| 3 | 1 | 8 | 9 (10.2%) | 13 | 12 | 25 (15.5%) | 24 | 91 | 115 (25%) | |
| 4 | 1 | 2 | 3 (3.4%) | – | – | – | 16 | 30 | 46 (10%) | |
| Other/NA | 4 | 3 | 7 (7.9%) | 6 | 6 | 12 (7.5%) | 2 | 7 | 9 (2%) | |
| Age at infection (y) (b) | Median (Q1–Q3) | 18 (11.5–23) | 29 (22–39) | 21 (17–27) | 36 (21–46) | 15 (8–18.5) | 23 (17–27.5) | |||
| Duration of infection (y) (c) | Median (Q1–Q3) | 30 (24–34.5) | 18 (14–26) | 24 (21–29) | 16 (12–19) | 32 (27–36) | 25 (18–31) | |||
(a)The threshold to define high alcohol consumption in the French cohorts and in the Swiss replication cohort were ≥30g/d and ≥40g/d, respectively. Alcohol consumption was missing in one patient with severe liver fibrosis in the Swiss replication cohort.
(b)Age at infection was missing in 77 patients with severe liver fibrosis in the Swiss replication cohort.
(c)Duration of infection was missing in 77 patients with severe liver fibrosis in the Swiss replication cohort.