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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: IEEE J Biomed Health Inform. 2018 Dec 28;23(5):2052–2062. doi: 10.1109/JBHI.2018.2890084

TABLE I.

Overview of the data used and analyses performed from the two studies.

Center Study 1: VUMC Study 2: BLSA
Data
Study population

  • Individuals with disease codes for glaucoma, intrinsic optic nerve disease, thyroid eye disease, optic nerve edema.

  • Individuals with hearing loss for controls.

  • Individuals from the Baltimore Longitudinal Study of Aging (BLSA).
Dataset E ICD-9 codes and demographic data for 29,214 individuals from the study population collected over all visits. ICD-9 codes and demographic data for 1,715 individuals from the study population collected over all visits.
Dataset RE Computed tomography (CT) imaging of the eye orbit for 1,451 subjects along with ICD-9 codes for all visits, and demographic data. Magnetic resonance imaging (MRI) of the brain of 124 subjects along with ICD-9 codes for all visits, and demographic data.
Analyses
Case-control experiments

  1. Glaucoma vs. healthy control

  2. Intrinsic optic nerve disease vs. healthy control

  3. Thyroid eye disease vs. healthy control

  4. Optic nerve edema vs. healthy control

  5. Glaucoma vs. other

  6. Intrinsic optic nerve disease vs. other

  7. Thyroid eye disease vs. other

  1. Diabetes vs. control