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. 2019 Nov 7;12:9355–9365. doi: 10.2147/OTT.S221228

Figure 1.

Figure 1

Tan IIA enhances the cytotoxic effect of gefitinib in gefitinib-resistance NSCLC cells. (A) The chemical structure of Tan IIA. (B) CCK-8 assay was used to detect the viability of NSCLC cells. HCC827 or HCC827/gefitinib cells were treated with 0, 5, 10, 20, 40, 80, 160 or 320 nM gefitinib for 72 hrs, respectively. (C) PC-9, PC-9/gefitinib cells were treated with 0, 5, 10, 20, 40, 80, 160 or 320 nM gefitinib for 72 hrs, respectively. (D) HCC827/gefitinib or PC-9/gefitinib cells were treated with 0, 1, 2, 4, 6, 8 or 16 μM Tan IIA for 72 hrs, respectively. (E) HCC827/gefitinib cells were treated with 40 nM OXA, or 40 nM OXA plus 2 μM Tan IIA for 72 hrs. (F) PC-9/gefitinib cells were treated with 40 nM OXA, or 40 nM OXA plus 2 μM Tan IIA for 72 hrs.