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. 2019 Nov 7;12:9355–9365. doi: 10.2147/OTT.S221228

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© 2019 Wang et al.

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Tan IIA enhances the sensitivity of HCC827/gefitinib cells to gefitinib in vivo. HCC827/gefitinib cells were injected subcutaneously into nude mice to form subcutaneous tumors. (A) Tumor volumes of mice were measured weekly. (B) HCC827/gefitinib xenograft tumors were excised from xenografts and pictured on day 21. (C) The weight in each group of mice was calculated on day 21. (D) Expression levels of p-EGFR, p-VEGFR2 and p-Akt in tumor tissues were measured with Western blotting. (E, F, G) The relative expressions of p-EGFR, p-VEGFR2 and p-Akt were quantified via normalization to β-actin. *P<0.05, **P<0.01 compared with control group; ^##P<0.01 compared with 150 mg/kg gefitinib group.