Table 2.
Baseline Characteristics Of AIS Patients With SAP And Non-SAP In Training Cohort
| Variables | Training Cohort (n=643) | ||
|---|---|---|---|
| Non-SAP (n=573) | SAP (n=70) | P-value | |
| Demographic characteristics | |||
| Age (years) | 65.5±11.9 | 73.3±10.0 | <0.001 |
| Gender | 0.797 | ||
| Male, n (%) | 361 (63.0%) | 43 (61.4%) | |
| Female, n (%) | 212 (37.0%) | 27 (38.6%) | |
| TOAST | 0.225 | ||
| Large-vessel disease | 452 (78.9%) | 52 (74.3%) | |
| Cardioembolism | 66 (11.5%) | 14 (20.0%) | |
| Lacunar | 42 (7.3%) | 3 (4.3%) | |
| Other | 6 (1.0%) | 0 (0.0%) | |
| Unknown | 7 (1.2%) | 1 (1.4%) | |
| Clinical parameters | |||
| NHISS score, median (IQR) | 2.0 (1.0–6.0) | 9.0 (4.2–12.0) | <0.001 |
| NHISS categories | <0.001 | ||
| 0–4 | 390 (68.1%) | 18 (25.7%) | |
| 5–15 | 158 (27.6%) | 40 (57.1%) | |
| ≥16 | 25 (4.4%) | 12 (17.1%) | |
| Thrombolysis, n (%) | 23 (4.0%) | 5 (7.1%) | 0.227 |
| Mechanical ventilation, n (%) | 24 (4.2%) | 12 (17.1%) | <0.001 |
| Nasogastric tubes intervention, n (%) | 41 (7.2%) | 35 (50.0%) | <0.001 |
| Current smoking, n (%) | 237 (41.4%) | 27 (38.6%) | 0.654 |
| Current drinking, n (%) | 210 (36.6%) | 26 (37.1%) | 0.936 |
| SBP (mmHg) | 153.3±24.5 | 156.9±23.8 | 0.245 |
| DBP (mmHg) | 83.0±13.6 | 84.5±12.8 | 0.386 |
| History of stroke, n (%) | 71 (12.4%) | 12 (17.1%) | 0.263 |
| Pre-existing comorbidities | |||
| Hypertension, n (%) | 463 (80.8%) | 58 (82.9%) | 0.679 |
| Diabetes, n (%) | 251 (43.8%) | 24 (34.3%) | 0.129 |
| Atrial fibrillation, n (%) | 57 (9.9%) | 31 (44.3%) | <0.001 |
| Coronary heart disease, n (%) | 11 (1.9%) | 1 (1.4%) | 0.774 |
| Congestive heart failure, n (%) | 15 (2.6%) | 4 (5.7%) | 0.149 |
| COPD, n (%) | 7 (1.2%) | 2 (2.9%) | 0.272 |
| Laboratory parameters | |||
| Fast blood glucose (mmol/L) | 6.5±2.5 | 7.1±3.7 | 0.076 |
| HDL-C (mmol/L) | 1.0±0.2 | 1.0±0.3 | 0.386 |
| LDL-C (mmol/L) | 2.7±1.0 | 2.8±1.0 | 0.635 |
| SCr (µmol/L) | 70.0 (59.0–85.0) | 71.5 (60.0–82.8) | 0.453 |
| GFR | 90.3 (76.7–102.7) | 88.8 (72.6–95.6) | 0.091 |
| Erythrocyte (×1012/L) | 4.4±0.5 | 4.4±0.6 | 0.760 |
| Hcy (µmol/L) | 12.0 (11.0–14.0) | 13.0 (11.0–15.0) | 0.201 |
| Leukocyte (×109/L) | 7.3±2.5 | 9.7±3.4 | 0.001 |
| Platelet (×109/L) | 224.5±68.6 | 214.4±83.0 | 0.256 |
| Hemoglobin (g/L) | 135.3±17.7 | 135.4±20.4 | 0.971 |
| Fibrinogen (g/L) | 3.6±1.1 | 4.4±1.6 | <0.001 |
| Total cholesterol (mmol/L) | 4.7±1.3 | 4.6±1.3 | 0.542 |
| Leukocyte categories (×109/L) | <0.001 | ||
| <10.0 | 483 (84.3%) | 31 (44.3%) | |
| ≥10.0 | 90 (15.7%) | 39 (55.7%) | |
| Fibrinogen categories (g/L) | <0.001 | ||
| <3.68 | 364 (64.0%) | 22 (31.4%) | |
| ≥3.68 | 205 (36.0%) | 48 (68.6%) | |
Abbreviations: COPD, chronic obstructive pulmonary disease; DBP, diastolic blood pressure; GFR, glomerular filtration rate; Hcy, homocysteine; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NIHSS, National Institutes of Health Stroke Scale; SAP, stroke-associated pneumonia; SBP, systolic blood pressure; SCr, serum creatinine concentration.