Table 2.

The total number of DEGs from various GSE series associated with TB disease.

Normal to Latent Infection
Up-regulated	Down-regulated
IER5L, MS4A6A, DOK2, FZD2, NCKI-ASI, SNHG12, NLRC4, XPO7, SMA4, CD36, AFFI, NDUFS8	IL1A, IL6, ACOD1, IL1B, ELOVL7, PTGS2, EREG, F3, IFIT1, TNF, KANK1, CCL4, CXCL11, PTX3, IRAK2, AREG
Normal to Active TB
Up-regulated	Down-regulated
GBP5, ISG15, SAMD9L, SERPING1, ANKRD22, ETV7, EPSTI1, GBP4, RSAD2, AIM2, IFI44, IFIT3, FGL2, FYB, MNDA, PAX5, OAS3, OAS1, IFI6, TNFSF10, UBE2L6, XAF1, STAT1, BST2, IFI35, STAT2, IFI44L, TRIM22, IFIH1, IFITM1, ATF3, BATF2, IFITM3, GBP1P1, RTP4, FCGR1B, C1QB, CEACAM1, FBXO6, SAMD4A, FRMD3, CMPK2, SELL, CFH, TLR8, LGALS3BP, SRGAP2, SECTM1, NCF1, SIGLEC1, APOL1, TRIM14, MB21D1, CARD16, FGD2, RNF213, CD163, PML, OAS2, OR52K3P, LY6E, RABGAP1L, P2RX7, NRG1, FBXO32, TYMP, PSMB9, NCF1C, PNPT1, CXCL13, GMPR, LAMP3, HESX1, C3AR1, STAT4, CXCL11, IFIT2, STAP1, ZC3H12A, RCAN1, HERC6, CCL20, CD83, CRIM1, GCH1, OASL, DLL4, MX2, EIF2AK2, EBI3, AXL, MGLL, CD80, IFIT5, IFIT1, CCL8, NFE2L3, PLSCR1, ICAM1, CXCL9, SLAMF7, CXCL10, HERC5, VCAM1, DDX58, NFKB1, SAMD9, IGFBP3, CCL3, CD274, BIRC3, IRF1, TAP1, PARP14, TMEM140, WARS, CASP1, GBP2, PSTPIP2, PARP9, RNASE6, FAM129C, FZD2, CD36, LRRK2, MS4A6A, CCR2, NAIP, FCRL2, P2RY13, CLEC7A, PCDH9, CD300LF, CLEC4A, C10orf54, BAIAP2-AS1, C1orf162, SORT1, JAK2, VAMP5, SCO2, ODF3B, PSME2, LOC101930164, P2RY14, GBP1, GBP6, CARD17, FCGR1A	RNF141, SLC25A37, ID3, EMP2, SKP2, SLC2A3, SUN1, KIT, OLR1, FLNB, CCDC14, GAPT, DHRS9, IQGAP3, SESN3, GINS4, HIST1H4C, CD44, KANK1, KCNJ2, TNIP3, MIR146A, CXCL3, LOC644090, MSC, SOD2, NLRP3, SERPINB9, TNFRSF9, ARL5B, IL24, ADORA2A, PHLDA1, MYO10, CXCL8, DNAAF1, MIR3945HG, NR3C1, TNFAIP6, SERPINB2, TNF, MAP3K8, IL1A, AGO2, CSF3, SPAG9, KYNU, LOC440934, WNT5A, DENND4A, ACOD1, PTGS2, OSM, CCL4, PFKFB3, EREG, ITGB8, PTX3, IL36G, G0S2, SLC7A11, ZC3H12C, TNFAIP3, IL6, CCRL2, FERMT2, SLCO4A1, SGPP2, FOSL2, CCL23, FLT1, SERPINB8, NUP98, SLC35F5, MN1, DDIT4, NAMPT, IRAK2, IL10, SLC7A5, AK4, CXCL2, UPB1, CEMIP, ADGRG2, FEZ1, THBS1, LACC1, CXCL1, TRAF1, PHLDA2, HEY1, LRP12, UBTD2, SLC39A8, PLPP3, SLC7A1, ATXN1, KMO, FNDC3B, IL1B, C11orf96, F3, PSEN1, BCAT1, GEM, TFPI2, PLAUR, MAFF, TRIM36, ZNF697, INSIG1, DPYSL3, ATP2B1, NCR3LG1, MAMLD1, ZNF540
Latent infection to Infection to Active TB
Up-regulated	Down-regulated
CLEC12B, CD36, CORO1B, SIGLEC16, LINC00484, AK5, MS4A6A, GPBAR1, RTN1, CREB5, DPYD, LDB2, FCN1, LRRK2, RASSF4, ANXA4, LPCAT2, SKAP2, CPPED1, RNASE2, PLSCR3, CLEC12A, BST1, FGD2, RAB3D, FGL2, PYCARD, CEBPA, MNDA, CD33, PRAM1, LILRA1, SLC39A11, TNFSF13, SAMHD1, DIAPH2, FAR2, MSRB1, TBCK, FARS2, C14orf159, MSRB2, ATG16L2, DPYSL2, AIF1, HK3, SIGLEC7, FYB, RPS6KA4, TBC1D5, C10orf11, AGTRAP, PYGL, CARD9, NAGA, SLC9A9, C1RL, STX8, MTHFD1, KCTD12, CBR1, ASCL2, CPNE8, MBNL3, ANXA6, CALML4, HSDL2, SLC22A18, KDM1B, IDH1, DNAJC10, TBXAS1, SCLT1, HSD17B4, MGST2, NAIP, JAML, ENTPD1, ASGR1, BLVRB, AOAH, NIPAL2, NAAA, RAB24, TST, COMT, COMMD10, CYFIP1, TALDO1, ULK2, HDAC9, RBCK1, CEACAM4, OBFC1, FUCA2, NREP, STX10, AKR7A2, PLOD1, TRIOBP, QDPR, FAM172A, CDK19, DPAGT1, PARVG, CLEC4A, SSBP4, PNKP, FBXL5, ASRGL1, CARS2, ATP11A, PLXNC1, TSPO, ARHGEF6, AGPAT3, HEXDC, PDSS2, PGM2, PRKCB, H2AFY, S100A9, SNX15, NINJ2, MAP4, PSTPIP1, GSTK1	IL1A, ITGB8, TFPI2, COL1A1, MET, SERPINB2, GPRC5A, SLC7A11, CYP1A1, RAB7B, B3GALT2, DUSP4, CXCL1, MMP19, THBS1, HEY1, PPP1R10, ADAMDEC1, PDE4DIP, CCRL2, LMNA, ZC3H12C, RGS13, CXCL5, PMEPA1, SKIL, LACC1, DPYSL4, ABCG1, AHRR, MIR155, EPHA4, CD109, MIR3945HG, NCR3LG1, WHRN, FAM177A1, SLC39A8, HEY2, C11orf96, KMO, CYP1B1, DUSP16, NFKB1, LZTS3, CXCR3, PLIN2, BIRC3, DOCK4, EPB41L3, MYO5C, ZHX2, CD58, P2RY10, CD82, MAPK8, PARD6G, NAB1, ABCB4, AMPD3, STK38L, SPECC1L, IL10RB-AS1, BANP, ETV6, PDCD4, MPZL3, CASC7, GGA2

These genes are classified into various categories of TB like normal to latent infections that contain 28 genes, normal to active TB diseases that contain 265 genes, and latent infection to active TB that contains 195 genes in this category.