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. 2019 Nov 7;12:9435–9447. doi: 10.2147/OTT.S222881

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© 2019 Yang et al.

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Regulatory mechanisms of GOF-MT SHP2 on cell malignancy. (A and B) Western blotting demonstrated the expression of SHP2, total ERK, p-ERK, total CREB, p-CREB, and several related downstream proteins (ie PCNA, cyclin D1, cyclin E1, MMP9) in normal, vector, WT-SHP2 and MT-SHP2 A172 and U87 cells. NS: no significant. The data are presented as the means ± SEM (**P<0.01 and ***P<0.001).

Abbreviations: GOF, gain-of-function; SHP2, Src homology-2 domain-containing protein-tyrosine phosphatase-2; WT, wild-type; MT, mutant; ERK, extracellular signal-regulated kinase; CREB, cAMP-response element-binding protein; MMP, matrix metallopeptidase; PCNA, proliferating cell nuclear antigen.