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. 2019 Aug 8;10(37):8610–8617. doi: 10.1039/c9sc02644d

Table 2. Phototoxicity of the PtIV complexes trans,trans,trans-[Pt(N3)2(OH)2(L1)(L2)] following irradiation with blue light (420 nm, 5 J cm–2, TL03, filtered <400 nm).Values are in μM.

Complex L1 L2 A2780
A2780cis
OE19
IC50 95% CI a PI IC50 95% CI PI IC50 95% CI PI
18 py 2-pic 14.5 12.7–16.7 7.3 d 15.5 11.2–21.5 5.3 d ND ND ND
19 py 3-pic 4.0 3.0–5.4 >51.5 3.3 1.9–5.9 >71.0 5.5 3.2–9.4 >38
20 py 4-pic 5.4 4.3–6.8 >38 4.6 3.8–5.6 >45 12.3 7.9–19.1 >17
23 3-pic 3-pic 7.2 6.0–8.7 >27.8 10.4 8.7–12.2 >19.3 ND ND ND
26 4-pic 4-pic 2.1 1.6–2.7 >95 4.1 3.3–5.1 >48.8 8.2 5.5–12.0 >24
29 Thiazole Thiazole 2.4 2.2–2.7 48 d 2.9 1.6–5.2 >71.0 7.6 5.4–10.7 >27
32 mim mim 56.3 40.2–78.9 >3.7 164.2 Wide >1.3 ND ND ND
FM165 c py NH3 25.4 22.2–29.1 >9.6 b ND ND ND ND ND ND
3 py py 6.7 3.6–13.7 >45 ND ND ND 8.4 ND >45

aPI = phototoxic index (ratio of cytotoxicity following irradiation vs. in the dark). Explicit cytotoxicity values in the dark will be added to the ESI if they become available.

bND = not determined.

cFM165 = trans,trans,trans-[Pt(N3)2(OH)2(NH3)(py)].

d= cytotoxic in the absence of irradiation. mim = 1-methylimidazole.