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. 2019 Oct 15;8(12):e1673126. doi: 10.1080/2162402X.2019.1673126

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — rs5743305 decreased the transcriptional activity of TLR3. (A) Wild type and −926T>A TLR3 plasmids were verified by direct sequencing. (B) Electrophoretic mobility shift assay (EMSA) showed that a much clearer DNA-protein complex was detected with the −926T probe than with the −926A probe. (C) Three luciferase reporter gene constructs were generated. They share identical backbone sequences except for the polymorphisms. (D) Significantly lower luciferase activity of the −926A haplotype was observed when compared with the wild type (−926T) haplotype vectors in the 468 cell line, MCF-7 cell line, and MDB-MB-231 breast cancer cell line.

* = P < .05; ** = P < .01.