Comparison 1. Cognitive function.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change of cognitive function measured by MMSE or ADAS‐cog+	3	420	Std. Mean Difference (IV, Random, 95% CI)	0.36 [0.13, 0.58]
2 Change of general cognitive function measured by MMSE	2	379	Mean Difference (IV, Random, 95% CI)	1.10 [0.37, 1.82]
3 Change of general cognitive function measured by ADAS‐cog+ score	2	273	Mean Difference (IV, Random, 95% CI)	‐4.21 [‐7.87, ‐0.56]
4 Improvement of general cognitive function reported as responder rates	3	338	Risk Ratio (M‐H, Random, 95% CI)	1.46 [1.10, 1.94]
5 Change of executive function measured by the Trail‐Making Test	2	526	Mean Difference (IV, Random, 95% CI)	‐24.75 [‐40.46, ‐9.03]