Comparison 5. Sensitivity analyses.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change of general cognitive function measured by MMSE	1	232	Mean Difference (IV, Fixed, 95% CI)	1.48 [0.06, 2.91]
2 Change of general cognitive function measured by ADAS‐cog+ score	1	232	Mean Difference (IV, Fixed, 95% CI)	‐6.11 [‐8.16, ‐4.06]
3 Improvement of general cognitive function reported as responder rates	1	232	Risk Ratio (M‐H, Fixed, 95% CI)	1.57 [1.29, 1.91]
4 Change of executive function measured by the Trail‐Making Test	1	232	Mean Difference (IV, Fixed, 95% CI)	‐15.31 [‐30.19, ‐0.43]
5 Improvement of global function reported as responder rates	1	232	Risk Ratio (M‐H, Fixed, 95% CI)	3.07 [1.86, 5.07]
6 Non‐serious adverse events	1	232	Risk Ratio (M‐H, Fixed, 95% CI)	1.54 [0.62, 3.84]