Table 1.

Inhibition of eeAChE and eqBuChE by compounds 4a-m and 9a-b.

					eeAChEa	eqBuChEb
Compd.	n	R	R1	R2	IC50 (μM)/Inhibition (%)	IC50 (μM)/Inhibition (%)
4a	2	A	H	H	45.3 ± 0.35%	16.69 ± 2.36%
4b	3	A	H	H	3.96 ± 0.71 μM	16.60 ± 4.01%
4c	4	A	H	H	0.22 ± 0.03 μM	45.37 ± 8.34%
4d	5	A	H	H	0.24 ± 0.02 μM	20.95 ± 2.61%
4e	6	A	H	H	0.35 ± 0.02 μM	17.49 ± 2.17%
4f	4	B	H	H	0.69 ± 0.22 μM	37.22 ± 1.22%
4g	4	C	H	H	9.61 ± 1.12 μM	31.43 ± 3.15%
4h	4	D	H	H	3.80 ± 0.35 μM	2.00 ± 0.23 μM
4i	4	E	H	H	20.17 ± 3.27%	15.81 ± 2.45%
4j	4	F	H	H	14.52 ± 2.44%	23.91 ± 2.03%
4k	4	G	H	H	23.14 ± 5.54%	28.65 ± 3.44%
4l	4	H	H	H	12.31 ± 1.76%	30.47 ± 4.11%
4m	4	I	H	H	31.43 ± 1.65%	7.63 ± 0.92%
9a	4	A	Me	H	0.30 ± 0.12 μM	18.31 ± 3.15%
9b	4	A	Me	Me	0.34 ± 0.01 μM	21.20 ± 1.60%
Donepezil	–	–	–	–	0.041 ± 0.002 μM	4.22 ± 0.20 μM
Galanthamine	–	–	–	–	1.65 ± 0.14 μM	11.68 ± 3.49 μM
Tacrine	–	–	–	–	0.21 ± 0.02 μM	0.057 ± 0.013 μM

^aThe 50% inhibitory concentration of eeAChE or percent inhibition with inhibitor at 10 μM (means ± SD of three experiments).

^bThe 50% inhibitory concentration of eqBuChE or percent inhibition with inhibitor at 10 μM (means ± SD of three experiments).