Table 2.
Permeability Pe(×10−6) in the PAMPA-BBB assay for 9 commercial drugs in the experiment validation.
| Commercial drugs | Bibliographya | Experimentb |
|---|---|---|
| Testosterone | 17.0 | 14.2 ± 3.6 |
| Estradiol | 12.0 | 10.2 ± 2.5 |
| Progesterone | 9.3 | 10.4 ± 1.9 |
| Chlorpromazine | 6.5 | 7.3 ± 2.3 |
| Corticosterone | 5.1 | 2.4 ± 0.8 |
| Hydrocortisone | 1.9 | 0.46 ± 0.12 |
| Caffeine | 1.3 | 1.2 ± 0.2 |
| Atenolol | 1.02 | 0.19 ± 0.23 |
| Theophylline | 0.1 | 0.16 ± 0.07 |
aAdapted from Di et al.26.
bExperimental data are expressed as mean ± SD from three independent experiments, using PBS: EtOH (70:30) as solvent.