Table 3.

Permeability P_e (×10⁶ cm/s) in the PAMPA-BBB assay for target compounds and their predicted penetration into CNS.

Compound	Pe (×106 cm/s)a	Predictionb
4a	8.57 ± 1.23	CNS+
4b	8.78 ± 1.11	CNS+
4c	8.91 ± 2.03	CNS+
4d	8.82 ± 1.34	CNS+
4e	9.85 ± 0.98	CNS+
4f	6.30 ± 0.86	CNS+
4g	7.14 ± 1.97	CNS+
4h	6.42 ± 1.02	CNS+
4i	2.83 ± 0.65	CNS±
4j	3.25 ± 0.82	CNS±
4k	4.54 ± 0.84	CNS+
4l	7.35 ± 1.05	CNS+
4m	10.00 ± 2.63	CNS+
9a	8.79 ± 2.10	CNS+
9b	8.67 ± 1.76	CNS+

^aPermeability P_e (×10⁶ cm/s) values are expressed as mean ± SD from three independent experiments, using PBS: EtOH (70:30) as solvent.

^bCNS + is predicted as high BBB permeation with P_e (×10⁶ cm/s) > 3.33, CNS ± is uncertain for BBB permeation with 1.51 < P_e (×10⁶ cm/s) < 3.33.