Table 4.

Inhibition of hAChE, and AChE- and self-induced Aβ_1-42 aggregation by selected compounds.

	hAChE	Inhibition of Aβ1–42 aggregation (%)
Compd.	IC50 (μM)a	AChE-inducedb	Self-inducedc
4c	0.16 ± 0.02	29.02 ± 2.06	30.67 ± 6.54
4d	0.57 ± 0.01	24.11 ± 3.04	26.01 ± 3.01
4e	0.38 ± 0.02	20.28 ± 2.21	25.82 ± 1.43
4f	1.21 ± 0.33	12.06 ± 3.18	20.35 ± 3.22
9a	0.76 ± 0.10	14.19 ± 2.85	33.36 ± 4.85
9b	0.39 ± 0.01	24.37 ± 3.03	35.29 ± 2.17
Donepezil	0.021 ± 0.001	26.16 ± 2.55	–
Tacrine	0.47 ± 0.03	–	–
Curcumin	–	–	37.27 ± 2.76

^aThe 50% inhibitory concentration of hAChE (means ± SD of three experiments).

^bInhibition of AChE-induced Aβ_1–42 aggregation. The thioflavin-T fluorescence method was used, and the concentration of the tested inhibitor was 100 μM (means ± SD of three experiments).

^cInhibition of self-induced Aβ_1-42 aggregation. The thioflavin-T fluorescence method was used, and the measurements were carried out in the presence of 25 μM inhibitor (means ± SD of three experiments).