Figure 4.

Statins treatments in S. cerevisiae results in an aberrant mitochondrial morphology phenotype, similar to that of rho° cells and this phenotype is suppressed by ergosterol. (a) W303 was treated with pravastatin 150 µg/ml, atorvastatin 100µg/ml and rosuvastatin 50 µg/ml grown in YPD and YPDE media in exponential growth phase; mitochondria were visualized with mitoGFP. (b) The histogram shows the percentage of cells with tubular mitochondria. As a control, W303 rho° strain was used. Bar: 2 µm. The magnification is the same in each picture.