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A hypothetical model of ATG2-mediated phagophore expansion. The C-terminal MAM localization domain (MLD) of ATG2 interacts with the TOMM40-TOMM70 complex to facilitate its N-terminal region binding to ATG9-positive donor membranes and ER for non-vesicular and/or vesicular lipid transport into the phagophore. Mito, mitochondrion; 40, TOMM40; 70, TOMM70.
