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. 2019 Nov 11;176(Suppl 1):S1–S20. doi: 10.1111/bph.14747
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2531 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2532 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2533 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2534 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2535
HGNC, UniProt https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3555, http://www.uniprot.org/uniprot/P07148 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3556, http://www.uniprot.org/uniprot/P12104 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3557, http://www.uniprot.org/uniprot/P05413 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3559, http://www.uniprot.org/uniprot/P15090 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3560, http://www.uniprot.org/uniprot/Q01469
Rank order of potency http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3377, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1054 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1055, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1052 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1049 [http://www.ncbi.nlm.nih.gov/pubmed/7929039?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3377 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1055,http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1054 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1052 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1049 [http://www.ncbi.nlm.nih.gov/pubmed/7929039?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3377, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1054, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1055 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1052, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1049, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391 [http://www.ncbi.nlm.nih.gov/pubmed/7929039?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1054, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1055, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3377, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1052 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1049, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391 [http://www.ncbi.nlm.nih.gov/pubmed/7929039?dopt=AbstractPlus]
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7186 (pK i 7.6) [http://www.ncbi.nlm.nih.gov/pubmed/18533710?dopt=AbstractPlus] – Rat, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2662 (pK i 6.5) [http://www.ncbi.nlm.nih.gov/pubmed/18533710?dopt=AbstractPlus] – Rat, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6736 (pK i 5.1) [http://www.ncbi.nlm.nih.gov/pubmed/19754198?dopt=AbstractPlus] – Mouse http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8797 (pK i 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/17502136?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8788 (pK i >9) [http://www.ncbi.nlm.nih.gov/pubmed/21481589?dopt=AbstractPlus]
Comments A broader substrate specificity than other FABPs, binding two fatty acids per protein [http://www.ncbi.nlm.nih.gov/pubmed/9054409?dopt=AbstractPlus]. Crystal structure of the rat FABP2 [http://www.ncbi.nlm.nih.gov/pubmed/2671390?dopt=AbstractPlus]. Crystal structure of the human FABP3 [http://www.ncbi.nlm.nih.gov/pubmed/7922029?dopt=AbstractPlus]. Crystal structure of the human FABP5 [http://www.ncbi.nlm.nih.gov/pubmed/10493790?dopt=AbstractPlus].