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. Author manuscript; available in PMC: 2019 Nov 11.
Published in final edited form as: Psychosom Med. 2019 Oct;81(8):731–738. doi: 10.1097/PSY.0000000000000717

Figure 1. (adapted with permission from Knowles, Ruiz, O’Connor, in press).

Figure 1

Broad Model of Acute and Chronic Alterations in Biomarkers Following Bereavement. Quadrants: A = Acute dysregulation, R = Resilient to changes, C = Chronic dysregulation, N = Normalized function. The vertical transition line refers to the time point where most individuals show normalization in parameters. The horizontal clinical cutoff line refers to the level at which parameters affect pathophysiology of disease. RR = relative risk.