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Hypothetic model of paracrine signalling of AGR2 in fibroblasts. In the initial signal, extracellular AGR2 could stimulate RhoA expression through FGFR and VEGFR. As a signalling cascade, increased RhoA expression upregulated G1-S phase cell cycle molecule cyclin D1 for proliferation mechanism. Another mechanism of AGR2 through RhoA expression could phosphorylate FAK for cytoskeleton reorganization and focal adhesion formation to promote cell migration.
