Table 1.

Gene Ontology (GO) enrichment analysis of A549 miR-146a RNA-Seq data. RNA-Seq data from A549 cells transfected with 50 nM of synthetic miR-146a or a non-targeting miRNA were used for GO enrichment analysis using g:Profiler. Genes were grouped based on their cellular function. Several groups with significant expression differences are listed below. Increased or decreased gene expression is based on expression levels post-miR-146a transfection (relative to the control).

Increased Gene Expression	p-value	Decreased Gene Expression	p-value
Development process	6.61 x 10−4	Mitotic cell cycle	4.08 x 10−2
Cell-cell signaling	4.17 x 10−3	DNA Replication	8.79 x 10−5
Cell killing	4.91 x 10−4	Cell cycle process	6.01 x 10−9
RNA processing	4.73 x 10−3	DNA repair	1.58 x 10−5
Negative regulation of transcription	4.45 x 10−2	Cellular component movement	3.74 x 10−2