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. 2019 Nov 11;176(Suppl 1):S247–S296. doi: 10.1111/bph.14751
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2019 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1798 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1799
Common abbreviation EGFR HER2 HER3 HER4
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3236, http://www.uniprot.org/uniprot/P00533 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3430, http://www.uniprot.org/uniprot/P04626 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3431, http://www.uniprot.org/uniprot/P21860 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3432, http://www.uniprot.org/uniprot/Q15303
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1
Endogenous ligands http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4916 (http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4916, http://www.uniprot.org/uniprot/P01133) (Binding), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4948 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3059, http://www.uniprot.org/uniprot/Q99075) (Binding), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5059 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11765, http://www.uniprot.org/uniprot/P01135) (Binding), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4864 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:651, http://www.uniprot.org/uniprot/P15514) (Binding), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4873 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1121, http://www.uniprot.org/uniprot/P35070) (Binding), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4917 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:17470, http://www.uniprot.org/uniprot/Q6UW88) (Binding), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4918 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3443, http://www.uniprot.org/uniprot/O14944) (Binding) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5027 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:7997, http://www.uniprot.org/uniprot/Q02297), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5029 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:7998, http://www.uniprot.org/uniprot/O14511) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4948 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3059, http://www.uniprot.org/uniprot/Q99075), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4873 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1121, http://www.uniprot.org/uniprot/P35070), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4918 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3443, http://www.uniprot.org/uniprot/O14944), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5027 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:7997, http://www.uniprot.org/uniprot/Q02297), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5029 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:7998, http://www.uniprot.org/uniprot/O14511), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5030 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:7999, http://www.uniprot.org/uniprot/P56975), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5031 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:29862, http://www.uniprot.org/uniprot/Q8WWG1)
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5667 (pK d 9.6) [http://www.ncbi.nlm.nih.gov/pubmed/22037378?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7944 (pIC50 9.5) [http://www.ncbi.nlm.nih.gov/pubmed/17575237?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5667 (pIC50 8–9.3) [http://www.ncbi.nlm.nih.gov/pubmed/20550212?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/18408761?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7903 (pIC50 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/21306821?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7883 (pIC50 7.9) [http://www.ncbi.nlm.nih.gov/pubmed/18500794?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7944 (pIC50 7.8) [http://www.ncbi.nlm.nih.gov/pubmed/17575237?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7879 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/20166197?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7903 (pIC50 7.6) [http://www.ncbi.nlm.nih.gov/pubmed/21306821?dopt=AbstractPlus]
Antibodies http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8090 (Binding) (pK d 9.5) [134], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6882 (Binding) (pK d 9.4) [70] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5046 (Inhibition) (pIC50 > 8) [106], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5082 (Inhibition)