Skip to main content
. 2019 Nov 11;176(Suppl 1):S247–S296. doi: 10.1111/bph.14751
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1808 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1809 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1810 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1811
Common abbreviation FGFR1 FGFR2 FGFR3 FGFR4
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3688, http://www.uniprot.org/uniprot/P11362 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3689, http://www.uniprot.org/uniprot/P21802 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3690, http://www.uniprot.org/uniprot/P22607 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3691, http://www.uniprot.org/uniprot/P22455
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.10.1
Endogenous ligands http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4923 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3665, http://www.uniprot.org/uniprot/P05230), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4924 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3676, http://www.uniprot.org/uniprot/P09038), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4925 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3682, http://www.uniprot.org/uniprot/P08620) > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4926 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3683, http://www.uniprot.org/uniprot/P12034), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4927 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3684, http://www.uniprot.org/uniprot/P10767) [http://www.ncbi.nlm.nih.gov/pubmed/8663044?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4923 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3665, http://www.uniprot.org/uniprot/P05230) > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4925 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3682, http://www.uniprot.org/uniprot/P08620), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4928 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3685, http://www.uniprot.org/uniprot/P21781), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4930 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3687, http://www.uniprot.org/uniprot/P31371) > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4924 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3676, http://www.uniprot.org/uniprot/P09038), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4927 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3684, http://www.uniprot.org/uniprot/P10767) [http://www.ncbi.nlm.nih.gov/pubmed/8663044?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9641 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3666, http://www.uniprot.org/uniprot/O15520) [http://www.ncbi.nlm.nih.gov/pubmed/12591959?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4923 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3665, http://www.uniprot.org/uniprot/P05230), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4924 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3676, http://www.uniprot.org/uniprot/P09038), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4930 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3687, http://www.uniprot.org/uniprot/P31371) > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4925 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3682, http://www.uniprot.org/uniprot/P08620), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4929 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3686, http://www.uniprot.org/uniprot/P55075) [http://www.ncbi.nlm.nih.gov/pubmed/8663044?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9629 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3681, http://www.uniprot.org/uniprot/P11487) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4923 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3665, http://www.uniprot.org/uniprot/P05230), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4924 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3676, http://www.uniprot.org/uniprot/P09038), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4925 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3682, http://www.uniprot.org/uniprot/P08620), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4930 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3687, http://www.uniprot.org/uniprot/P31371) > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4927 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3684, http://www.uniprot.org/uniprot/P10767), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4929 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3686, http://www.uniprot.org/uniprot/P55075) [http://www.ncbi.nlm.nih.gov/pubmed/8663044?dopt=AbstractPlus]
Sub/family‐selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8104 (pIC50 8.6) [http://www.ncbi.nlm.nih.gov/pubmed/21900693?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8104 (pIC50 8.6) [http://www.ncbi.nlm.nih.gov/pubmed/21900693?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8104 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/21900693?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8104 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/21900693?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8862 (Irreversible inhibition) (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/25776529?dopt=AbstractPlus]
Agonists http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6954