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. 2019 Nov 11;176(Suppl 1):S247–S296. doi: 10.1111/bph.14751
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1871 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1872 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1873 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1875 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2322
Systematic nomenclature TNFRSF1A TNFRSF1B TNFRSF3 TNFRSF4 TNFRSF5 TNFRSF6 TNFRSF6B
Common abbreviation TNFR1 TNFR2
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11916, http://www.uniprot.org/uniprot/P19438 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11917, http://www.uniprot.org/uniprot/P20333 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6718, http://www.uniprot.org/uniprot/P36941 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11918, http://www.uniprot.org/uniprot/P43489 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874, http://www.uniprot.org/uniprot/P25942 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1875, http://www.uniprot.org/uniprot/P25445 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11921, http://www.uniprot.org/uniprot/O95407
Adaptor proteins TRADD TRAF1, TRAF2, TRAF5 TRAF3, TRAF4, TRAF5 TRAF1, TRAF2, TRAF3, TRAF5 TRAF1, TRAF2, TRAF3, TRAF5, TRAF6 FADD
Endogenous ligands http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5064 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6709, http://www.uniprot.org/uniprot/P01374), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5073 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11892, http://www.uniprot.org/uniprot/P01375), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5074 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11892, http://www.uniprot.org/uniprot/P01375) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5064 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6709, http://www.uniprot.org/uniprot/P01374), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5073 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11892, http://www.uniprot.org/uniprot/P01375) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5070 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11930, http://www.uniprot.org/uniprot/O43557), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6142 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6142 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6709 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6711, http://www.uniprot.org/uniprot/P01374 http://www.uniprot.org/uniprot/Q06643) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5076 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11934, http://www.uniprot.org/uniprot/P23510) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5077 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11935, http://www.uniprot.org/uniprot/P29965) http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5078 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11936, http://www.uniprot.org/uniprot/P48023)
Ligands http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9092 (Binding) (pIC50 5.9) [http://www.ncbi.nlm.nih.gov/pubmed/24930776?dopt=AbstractPlus]
Comments The OX40/OX40L pair is involved in late T‐cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [http://www.ncbi.nlm.nih.gov/pubmed/26215166?dopt=AbstractPlus] Decoy receptor for http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5070 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11930, http://www.uniprot.org/uniprot/O43557), http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5071 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11931, http://www.uniprot.org/uniprot/O95150) and http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5078 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11936, http://www.uniprot.org/uniprot/P48023).