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. 2019 Nov 11;176(Suppl 1):S247–S296. doi: 10.1111/bph.14751
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1894 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1895 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1896 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2325
Systematic nomenclature TNFRS27
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:17756, http://www.uniprot.org/uniprot/Q9HAV5 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2895, http://www.uniprot.org/uniprot/Q9UNE0
Adaptor proteins TRAF1, TRAF3, TRAF6 TRAF1, TRAF2, TRAF3
Endogenous ligands http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1896 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3157, http://www.uniprot.org/uniprot/Q92838) [http://www.ncbi.nlm.nih.gov/pubmed/11039935?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2325 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3157, http://www.uniprot.org/uniprot/Q92838) [http://www.ncbi.nlm.nih.gov/pubmed/11039935?dopt=AbstractPlus]
Comments Only identified in mouse to date. A potential decoy receptor for the cytotoxic ligand TNFSF10/TRAIL. Does not contain a cytoplasmic death domain so does not induce apoptosis, and does not activate the NF‐κB signalling pathway. Only identified in mouse to date. A potential decoy receptor for the cytotoxic ligand TNFSF10/TRAIL. Does not contain a cytoplasmic death domain so does not induce apoptosis, and does not activate the NF‐κB signalling pathway. Receptor for the EDA‐A2 isoform of ectodysplasin encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Cell surface receptor for ectodysplasin A (a morphogen involved in the development of ectodermal tissues, including skin, hair, nails, teeth, and sweat glands).