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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2480 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2471
Common abbreviation ChAT AChE BChE
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1912, http://www.uniprot.org/uniprot/P28329 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:108, http://www.uniprot.org/uniprot/P22303 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:983, http://www.uniprot.org/uniprot/P06276
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.6: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3038 + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4551 = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=294 + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.7: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=294 + H2O = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1058 + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4551 + H+ http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.7: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=294 + H2O = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1058 + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4551 + H+
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8807 (pIC50 6.5) [http://www.ncbi.nlm.nih.gov/pubmed/3351860?dopt=AbstractPlus] – Mouse http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6687 (pK i 7.5) [http://www.ncbi.nlm.nih.gov/pubmed/18479118?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6693 (pIC50 6.3) [http://www.ncbi.nlm.nih.gov/pubmed/12182861?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6602 (pIC50 5.4) [http://www.ncbi.nlm.nih.gov/pubmed/16570913?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6602 (pIC50 7.4) [http://www.ncbi.nlm.nih.gov/pubmed/16570913?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6687 (pK i 7.2) [http://www.ncbi.nlm.nih.gov/pubmed/18479118?dopt=AbstractPlus]
Sub/family‐selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6598 (pIC50 7.6–7.8) [http://www.ncbi.nlm.nih.gov/pubmed/16570913?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6598 (pIC50 7.6–7.8) [http://www.ncbi.nlm.nih.gov/pubmed/16570913?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6599 (pIC50 7.7–8.3) [http://www.ncbi.nlm.nih.gov/pubmed/1738151?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8039548?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/16570913?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6600 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/12675140?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6601 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/12675140?dopt=AbstractPlus]
Comments Splice variants of choline O‐acetyltransferase are suggested to be differentially distributed in the periphery and CNS (see [http://www.ncbi.nlm.nih.gov/pubmed/21382474?dopt=AbstractPlus]).