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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1270 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1271 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1275 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1276 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1277 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1269
Common abbreviation ADC AADC MLYCD ODC PSDC SAMDC
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:29957, http://www.uniprot.org/uniprot/Q96A70 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2719, http://www.uniprot.org/uniprot/P20711 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:7150, http://www.uniprot.org/uniprot/O95822 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8109, http://www.uniprot.org/uniprot/P11926 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8999, http://www.uniprot.org/uniprot/Q9UG56 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:457, http://www.uniprot.org/uniprot/P17707
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.19 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.28: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=940 + CO2 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4671 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5 + CO2 This enzyme also catalyses the following reaction:: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=717 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=125 + CO2 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.9 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.17 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.65 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.50
Endogenous substrates http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=721 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4671, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=717 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5219 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=725 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3638 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4786
Products http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4127 [http://www.ncbi.nlm.nih.gov/pubmed/14738999?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=940 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3038 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2388 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2796 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5121
Cofactors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4809 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4809
Selective inhibitors – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5116, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5217, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5150 [http://www.ncbi.nlm.nih.gov/pubmed/22384042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5159 – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5139 (pIC50 7.5) [http://www.ncbi.nlm.nih.gov/pubmed/1573631?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5176 (pK d 4.9) [http://www.ncbi.nlm.nih.gov/pubmed/12859253?dopt=AbstractPlus] – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5268 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/8340919?dopt=AbstractPlus]
Comments The presence of a functional ADC activity in human tissues has been questioned [http://www.ncbi.nlm.nih.gov/pubmed/14763899?dopt=AbstractPlus]. AADC is a homodimer. Inhibited by AMP‐activated protein kinase‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/10854420?dopt=AbstractPlus] The activity of ODC is regulated by the presence of an antizyme (http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104904;r=19:2269520‐2273487;t=ENST00000322297) and an ODC antizyme inhibitor (http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155096;r=8:103838585‐103906092). S‐allylglycine is also an inhibitor of SAMDC [http://www.ncbi.nlm.nih.gov/pubmed/438812?dopt=AbstractPlus]. http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5267 is also an inhibitor of SAMDC [http://www.ncbi.nlm.nih.gov/pubmed/438812?dopt=AbstractPlus].