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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1613
Common abbreviation ACE
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2707, http://www.uniprot.org/uniprot/P12821
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:3.4.15.1
Substrates http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10060
Endogenous substrates http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=583 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:333, http://www.uniprot.org/uniprot/P01019) > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2504 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:333, http://www.uniprot.org/uniprot/P01019)
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6463 (pK i 9.4) [http://www.ncbi.nlm.nih.gov/pubmed/2836590?dopt=AbstractPlus] – Rabbit, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5158 (pKi 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/9187274?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6462
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6373 (pIC50 9) [http://www.ncbi.nlm.nih.gov/pubmed/17716647?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6461 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/2527528?dopt=AbstractPlus] – Rabbit, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6378 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/17547476?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7893 (C‐domain assay) (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/20233165?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7894 (N‐domain selective inhibition) (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/22628311?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6457 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/2481187?dopt=AbstractPlus] – Rabbit, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6332 (pIC50 7.5) [http://www.ncbi.nlm.nih.gov/pubmed/7527095?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6375 (pIC50 6.6) [http://www.ncbi.nlm.nih.gov/pubmed/17506720?dopt=AbstractPlus]
Comments Reports of ACE GPI hydrolase activity [http://www.ncbi.nlm.nih.gov/pubmed/15665832?dopt=AbstractPlus] have been refuted [http://www.ncbi.nlm.nih.gov/pubmed/16270062?dopt=AbstractPlus]