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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:3788, http://www.uniprot.org/uniprot/Q04609
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:3.4.17.21
Antibodies http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6878 (Binding)
Comments Folate hydrolase is also known as NAALADase as it is responsible for the hydrolysis of N‐acetaspartylglutamate to form N‐acetylaspartate and L‐glutamate (http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369). In the gut, the enzyme assists in the assimilation of folate by hydrolysing dietary poly‐gamma‐glutamylfolate. The enzyme is highly expressed in the prostate, and its expression is up‐regulated in cancerous tissue. A tagged version of the antibody http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6878 has been used for imaging purposes.