Nomenclature	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1240	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2527	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2486
Common abbreviation	–	TAT	–	DBH
HGNC, UniProt	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8582, http://www.uniprot.org/uniprot/P00439	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11573, http://www.uniprot.org/uniprot/P17735	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11782, http://www.uniprot.org/uniprot/P07101	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2689, http://www.uniprot.org/uniprot/P09172
EC number	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.16.1: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3313 + O2 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791	http://www.genome.jp/dbget‐bin/www_bget?ec:2.6.1.5: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791 + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3636 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6629 + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.16.2: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791 + O2 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.17.1: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=940 + O2 = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=505 + H2O
Endogenous substrates	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3313	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791	–
Products	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639	–
Cofactors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5276	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5276, Fe2+	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4164, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4781
Endogenous activators	Protein kinase A‐mediated phosphorylation (Rat) [http://www.ncbi.nlm.nih.gov/pubmed/182695?dopt=AbstractPlus]	–	Protein kinase A‐mediated phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/33381?dopt=AbstractPlus]	–
Selective inhibitors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5093 [http://www.ncbi.nlm.nih.gov/pubmed/944951?dopt=AbstractPlus] – Rat, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5240	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5095, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5114, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5117, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6956	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6630 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/9283721?dopt=AbstractPlus]
Comments	PAH is an iron bound homodimer or ‐tetramer from the same structural family as tyrosine 3‐monooxygenase and the tryptophan hydroxylases. Deficiency or loss‐of‐function of PAH is associated with http://omim.org/entry/612349	Tyrosine may also be metabolized in the liver by tyrosine transaminase to generate http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6629, which can be further metabolized to homogentisic acid. TAT is a homodimer, where loss‐of‐function mutations are associated with http://omim.org/entry/276600.	TH is a homotetramer, which is inhibited by dopamine and other catecholamines in a physiological negative feedback pathway [http://www.ncbi.nlm.nih.gov/pubmed/21176768?dopt=AbstractPlus].	DBH is a homotetramer. A protein structurally‐related to DBH (http://www.genenames.org/data/hgnc_data.php?hgnc_id=21063, http://www.uniprot.org/uniprot/Q6UVY6) has been described and for which a function has yet to be identified [http://www.ncbi.nlm.nih.gov/pubmed/9751809?dopt=AbstractPlus].