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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2526 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2481 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2482 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2483 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2488
Common abbreviation TPO DIO1 DIO2 DIO3 IYD
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:12015, http://www.uniprot.org/uniprot/P07202 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2883, http://www.uniprot.org/uniprot/P49895 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2884, http://www.uniprot.org/uniprot/Q92813 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2885, http://www.uniprot.org/uniprot/P55073 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:21071, http://www.uniprot.org/uniprot/Q6PHW0
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:1.11.1.8: [Thyroglobulin]‐L‐tyrosine + http://www.genome.jp/dbget‐bin/www_bget?ec:1.97.1.10 + H+ + I ‐> [Thyroglobulin]‐3,5,3′‐triiodo‐L‐thyronine + [thyroglobulin]‐aminoacrylate + H2O http://www.genome.jp/dbget‐bin/www_bget?ec:1.97.1.10: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2635 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2634 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2636 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6648 http://www.genome.jp/dbget‐bin/www_bget?ec:1.97.1.10: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2635 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2634 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2636 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6648 http://www.genome.jp/dbget‐bin/www_bget?ec:1.97.1.11: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2635 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2634 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2636 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6648 http://www.genome.jp/dbget‐bin/www_bget?ec:1.22.1.1: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5117 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791 + I http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6651 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5117 + I
Cofactors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=707 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5184, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3041
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6649 [http://www.ncbi.nlm.nih.gov/pubmed/748042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6650 [http://www.ncbi.nlm.nih.gov/pubmed/748042?dopt=AbstractPlus]
Comments Carbimazole is a pro‐drug for http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6649