Nomenclature	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1271	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2496	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2472
Common abbreviation	AADC	PNMT	COMT
HGNC, UniProt	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2719, http://www.uniprot.org/uniprot/P20711	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9160, http://www.uniprot.org/uniprot/P11086	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2228, http://www.uniprot.org/uniprot/P21964
EC number	http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.28: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=940 + CO2 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4671 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5 + CO2 This enzyme also catalyses the following reaction:: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=717 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=125 + CO2	http://www.genome.jp/dbget‐bin/www_bget?ec:2.1.1.28: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=505 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=479	http://www.genome.jp/dbget‐bin/www_bget?ec:2.1.1.6: S‐adenosyl‐L‐methionine + a catechol = S‐adenosyl‐L‐homocysteine + a guaiacol http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=505 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6643 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=940 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6642 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6633 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6645 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=479 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6644
Endogenous substrates	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4671, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=717	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4786
Products	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=940	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6646 (soluble enzyme) (pK i 9.6) [http://www.ncbi.nlm.nih.gov/pubmed/7703232?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6646 (membrane‐bound enzyme) (pK i 9.5) [http://www.ncbi.nlm.nih.gov/pubmed/7703232?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6647 (soluble enzyme) (pK i 9.5) [http://www.ncbi.nlm.nih.gov/pubmed/7703232?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6647 (membrane‐bound enzyme) (pK i 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/7703232?dopt=AbstractPlus]
Cofactors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4786	–
Inhibitors	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6631 (pK i 7.6) [http://www.ncbi.nlm.nih.gov/pubmed/6268095?dopt=AbstractPlus]	COMT appears to exist in both membrane‐bound and soluble forms. COMT has also been described to methylate steroids, particularly hydroxyestradiols
Selective inhibitors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5116, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5217, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5150 [http://www.ncbi.nlm.nih.gov/pubmed/22384042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5159	–	–
Comments	AADC is a homodimer.	–	–