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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2474 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2475 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2476 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2477 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2478 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2479
Common abbreviation CERS1 CERS2 CERS3 CERS4 CERS5 CERS6
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:14253, http://www.uniprot.org/uniprot/P27544 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:14076, http://www.uniprot.org/uniprot/Q96G23 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:23752, http://www.uniprot.org/uniprot/Q8IU89 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:23747, http://www.uniprot.org/uniprot/Q9HA82 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:23749, http://www.uniprot.org/uniprot/Q8N5B7 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:23826, http://www.uniprot.org/uniprot/Q6ZMG9
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.24: acylCoA+ http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2453 ‐> dihydroceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2452 + acylCoA ‐> ceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.24: acylCoA + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2453 ‐> dihydroceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2452 + acylCoA ‐> ceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.24: acylCoA + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2453 ‐> dihydroceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2452 + acylCoA ‐> ceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.24: acylCoA + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2453 ‐> dihydroceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2452 + acylCoA ‐> ceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.24: acylCoA + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2453 ‐> dihydroceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2452 + acylCoA ‐> ceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.genome.jp/dbget‐bin/www_bget?ec:2.3.1.24: acylCoA + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2453 ‐> dihydroceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2452 + acylCoA ‐> ceramide + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3044
Substrates C18‐CoA [http://www.ncbi.nlm.nih.gov/pubmed/12105227?dopt=AbstractPlus] C24‐ and C26‐CoA [http://www.ncbi.nlm.nih.gov/pubmed/18165233?dopt=AbstractPlus] C26‐CoA and longer [http://www.ncbi.nlm.nih.gov/pubmed/14511335?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/18308723?dopt=AbstractPlus] C18‐, C20‐ and C22‐CoA [http://www.ncbi.nlm.nih.gov/pubmed/12912983?dopt=AbstractPlus] C16‐CoA [http://www.ncbi.nlm.nih.gov/pubmed/16100120?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/12912983?dopt=AbstractPlus] C14‐ and C16‐CoA [http://www.ncbi.nlm.nih.gov/pubmed/15823095?dopt=AbstractPlus]