Nomenclature	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1230	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1231	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1232	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1233
Systematic nomenclature	–	–	CD73	–
Common abbreviation	ADA	ADK	NT5E	SAHH
HGNC, UniProt	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:186, http://www.uniprot.org/uniprot/P00813	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:257, http://www.uniprot.org/uniprot/P55263	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8021, http://www.uniprot.org/uniprot/P21589	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:343, http://www.uniprot.org/uniprot/P23526
EC number	http://www.genome.jp/dbget‐bin/www_bget?ec:3.5.4.4: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2844 + H2O = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4554 + NH3	http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.1.20	http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.3.5	http://www.genome.jp/dbget‐bin/www_bget?ec:3.3.1.1
Rank order of affinity	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5109 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2844	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2844	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2455, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5123, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5124, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5125 > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5120, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5122	–
Endogenous substrates	–	–	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5265
Products	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5110, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4554	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2455	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4566, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4554, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4556, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2844	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2844
Inhibitors	–	–	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8392 (pK i 12.3) [http://www.ncbi.nlm.nih.gov/pubmed/3457563?dopt=AbstractPlus] – Hamster
Selective inhibitors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4805 (pIC50 10.8) [http://www.ncbi.nlm.nih.gov/pubmed/849330?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5179 (pK i 8.8) [http://www.ncbi.nlm.nih.gov/pubmed/849330?dopt=AbstractPlus]	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5130 (pIC50 10.2) [http://www.ncbi.nlm.nih.gov/pubmed/11160637?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5131 (pIC50 8.8) [http://www.ncbi.nlm.nih.gov/pubmed/11082453?dopt=AbstractPlus]	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5092 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/1169962?dopt=AbstractPlus]	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5115 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/7470463?dopt=AbstractPlus]
Comments	–	The enzyme exists in two isoforms derived from alternative splicing of a single gene product: a short isoform, ADK‐S, located in the cytoplasm is responsible for the regulation of intra‐ and extracellular levels of adenosine and hence adenosine receptor activation; a long isoform, ADK‐L, located in the nucleus contributes to the regulation of DNA methylation [http://www.ncbi.nlm.nih.gov/pubmed/23592612?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/23863710?dopt=AbstractPlus].	Pharmacological inhibition of CD73 is being investigated as a novel cancer immunotherapy strategy [http://www.ncbi.nlm.nih.gov/pubmed/21537079?dopt=AbstractPlus].	–