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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1278 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1279 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1280 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1281 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1282
Common abbreviation AC1 AC2 AC3 AC4 AC5
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:232, http://www.uniprot.org/uniprot/Q08828 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:233, http://www.uniprot.org/uniprot/Q08462 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:234, http://www.uniprot.org/uniprot/O60266 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:235, http://www.uniprot.org/uniprot/Q8NFM4 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:236, http://www.uniprot.org/uniprot/O95622
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1
Endogenous activators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2351 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1445, http://www.uniprot.org/uniprot/P62158), PKC‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/8440678?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/2022671?dopt=AbstractPlus] Gβγ, PKC‐evoked phosphorylation, Raf‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/8389756?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/15385642?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8390980?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8416978?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2351 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1445, http://www.uniprot.org/uniprot/P62158), PKC‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/1633161?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8440678?dopt=AbstractPlus] Gβγ [http://www.ncbi.nlm.nih.gov/pubmed/1946437?dopt=AbstractPlus] PKC‐evoked phophorylation, Gβγ, Raf‐evoked phophorylation [http://www.ncbi.nlm.nih.gov/pubmed/15385642?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/17110384?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8206971?dopt=AbstractPlus]
Activators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8809 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/8709105?dopt=AbstractPlus] – Bovine http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10214 [http://www.ncbi.nlm.nih.gov/pubmed/11602596?dopt=AbstractPlus] – – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10215 [http://www.ncbi.nlm.nih.gov/pubmed/11602596?dopt=AbstractPlus]
Endogenous inhibitors Gαi, Gαo, Gbg [http://www.ncbi.nlm.nih.gov/pubmed/8416978?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8119955?dopt=AbstractPlus] – http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2808, Gβγ, CaM kinase II‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/16275644?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/11234015?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/7665559?dopt=AbstractPlus] PKC‐evoked phophorylation [http://www.ncbi.nlm.nih.gov/pubmed/8900209?dopt=AbstractPlus] Gαi, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=707, PKA‐evoked phosphorylation, Gβγ, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2509 [http://www.ncbi.nlm.nih.gov/pubmed/17110384?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/10781930?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/1618857?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/7759492?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8119955?dopt=AbstractPlus]
Inhibitors – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=944 [http://www.ncbi.nlm.nih.gov/pubmed/24008337?dopt=AbstractPlus] – – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5233 (pIC50 5.2) [http://www.ncbi.nlm.nih.gov/pubmed/24006339?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/11602596?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10092 (pIC50 5.6) [http://www.ncbi.nlm.nih.gov/pubmed/28223412?dopt=AbstractPlus] – – – –
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1283 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1284 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1285 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1286 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3068
Common abbreviation AC6 AC7 AC8 AC9 AC10
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:237, http://www.uniprot.org/uniprot/O43306 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:238, http://www.uniprot.org/uniprot/P51828 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:239, http://www.uniprot.org/uniprot/P40145 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:240, http://www.uniprot.org/uniprot/O60503 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:21285, http://www.uniprot.org/uniprot/Q96PN6
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:4.6.1.1 –
Endogenous activators Gβγ, Raf‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/15385642?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/17110384?dopt=AbstractPlus] Gβγ, PKC‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/15581358?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/7961850?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2351 (https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1445, http://www.uniprot.org/uniprot/P62158) [http://www.ncbi.nlm.nih.gov/pubmed/8163524?dopt=AbstractPlus] – Bicarbonate, Ca2+ [http://www.ncbi.nlm.nih.gov/pubmed/10915626?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/12609998?dopt=AbstractPlus]
Endogenous inhibitors Gαi, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=707, PKA‐evoked phosphorylation, PKC‐evoked phosphorylation, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2509 [http://www.ncbi.nlm.nih.gov/pubmed/9391159?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/10781930?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/10462552?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/8119955?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/1379717?dopt=AbstractPlus] – PKA‐evoked phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/22976297?dopt=AbstractPlus] Ca2+/calcineurin [http://www.ncbi.nlm.nih.gov/pubmed/10987815?dopt=AbstractPlus] –
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5233 (pIC50 4.8) [http://www.ncbi.nlm.nih.gov/pubmed/24006339?dopt=AbstractPlus] – – – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10216 (pIC50 5–5.5) [http://www.ncbi.nlm.nih.gov/pubmed/16054031?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10023 (pIC50 5) [http://www.ncbi.nlm.nih.gov/pubmed/27547922?dopt=AbstractPlus]