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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1297 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1298 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1299
Common abbreviation PDE2A PDE3A PDE3B
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8777, http://www.uniprot.org/uniprot/O00408 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8778, http://www.uniprot.org/uniprot/Q14432 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8779, http://www.uniprot.org/uniprot/Q13370
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.4.17 http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.4.17 http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.4.17
Rank order of affinity http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2352http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2347
Endogenous activators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2347
Endogenous inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2347 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2347
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5225 (pIC50 <6.5) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7148 (pIC50 6.7) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7202 (pIC50 4.8) [http://www.ncbi.nlm.nih.gov/pubmed/2536438?dopt=AbstractPlus]
Sub/family‐selective inhibitors
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5147 (pIC50 8.3–8.8) [http://www.ncbi.nlm.nih.gov/pubmed/15555642?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5179 (pIC50 5.3) [http://www.ncbi.nlm.nih.gov/pubmed/8730511?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5167 (pIC50 7.5) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7114 (pIC50 7.1–7.3) [http://www.ncbi.nlm.nih.gov/pubmed/3027338?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/1311763?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/1321910?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5225 (pIC50 6.3–6.4) [http://www.ncbi.nlm.nih.gov/pubmed/14592490?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5167 (pIC50 7.3) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7148 (pIC50 6.4) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5225 (pIC50 6) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7202 (pIC50 4.5) [http://www.ncbi.nlm.nih.gov/pubmed/10644042?dopt=AbstractPlus]
Comments http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5179 is also an inhibitor of http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=248#show_object_1230 (http://www.genome.jp/kegg‐bin/search_brite?option=‐a&search_string=3.5.4.4).