Nomenclature	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1240	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1241	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1242
HGNC, UniProt	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8582, http://www.uniprot.org/uniprot/P00439	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11782, http://www.uniprot.org/uniprot/P07101	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:12008, http://www.uniprot.org/uniprot/P17752	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:20692, http://www.uniprot.org/uniprot/Q8IWU9
EC number	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.16.1: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3313 + O2 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.16.2: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791 + O2 ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.16.4	http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.16.4
Endogenous substrates	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3313	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=717	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=717
Products	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4791	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4671	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4671
Cofactors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5276	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5276, Fe2+	–	–
Endogenous activators	Protein kinase A‐mediated phosphorylation (Rat) [http://www.ncbi.nlm.nih.gov/pubmed/182695?dopt=AbstractPlus]	Protein kinase A‐mediated phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/33381?dopt=AbstractPlus]	Protein kinase A‐mediated phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/8592157?dopt=AbstractPlus]	Protein kinase A‐mediated phosphorylation [http://www.ncbi.nlm.nih.gov/pubmed/8592157?dopt=AbstractPlus]
Inhibitors	–	–	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9490 [http://www.ncbi.nlm.nih.gov/pubmed/26206858?dopt=AbstractPlus]	–
Selective inhibitors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5093 [http://www.ncbi.nlm.nih.gov/pubmed/944951?dopt=AbstractPlus] – Rat, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5240	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5095, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5114, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5117, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6956	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5095, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5126 [http://www.ncbi.nlm.nih.gov/pubmed/6457252?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5240, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4613	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5095, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5126 [http://www.ncbi.nlm.nih.gov/pubmed/6457252?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5240, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4613
Comments	PAH is an iron bound homodimer or ‐tetramer from the same structural family as tyrosine 3‐monooxygenase and the tryptophan hydroxylases. Deficiency or loss‐of‐function of PAH is associated with http://omim.org/entry/612349	TH is a homotetramer, which is inhibited by dopamine and other catecholamines in a physiological negative feedback pathway [http://www.ncbi.nlm.nih.gov/pubmed/21176768?dopt=AbstractPlus].	–	–