Skip to main content
. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1353 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1354 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1355 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1356 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1357
Common abbreviation Thromboxane synthase Prostacyclin synthase
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:11609, http://www.uniprot.org/uniprot/P24557 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2651, http://www.uniprot.org/uniprot/P22680 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2652, http://www.uniprot.org/uniprot/O75881 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9603, http://www.uniprot.org/uniprot/Q16647 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:2653, http://www.uniprot.org/uniprot/Q9UNU6
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:5.3.99.5: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4483 = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4482 http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.14.23 http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.14.29 http://www.genome.jp/dbget‐bin/www_bget?ec:5.3.99.4 http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.14.139 http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.18.8
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9866 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/3093741?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8795 (pIC50 >6) [http://www.ncbi.nlm.nih.gov/pubmed/7861416?dopt=AbstractPlus]
Comments Inhibited by http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5175 [http://www.ncbi.nlm.nih.gov/pubmed/6795753?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5157 [http://www.ncbi.nlm.nih.gov/pubmed/7778318?dopt=AbstractPlus] and furegrelate sodium (U‐63557A: PubChem https://pubchem.ncbi.nlm.nih.gov/compound/23663954) [http://www.ncbi.nlm.nih.gov/pubmed/6316421?dopt=AbstractPlus]. Converts http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2718 to http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4351 [http://www.ncbi.nlm.nih.gov/pubmed/2384150?dopt=AbstractPlus]. Converts http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2370 to 7α‐DHEA [http://www.ncbi.nlm.nih.gov/pubmed/9144166?dopt=AbstractPlus]. Converts http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4483 to http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1915 [http://www.ncbi.nlm.nih.gov/pubmed/8766713?dopt=AbstractPlus]. Inhibited by http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5281 [http://www.ncbi.nlm.nih.gov/pubmed/824685?dopt=AbstractPlus] Converts 7α‐hydroxycholest‐4‐en‐3‐one to 7‐alpha, 12α‐dihydroxycholest‐4‐en‐3‐one (in rabbit) [http://www.ncbi.nlm.nih.gov/pubmed/1400444?dopt=AbstractPlus] in the biosynthesis of bile acids.