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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1396 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1397 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1399 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2919 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3070
Common abbreviation DAGLα DAGLß MAGL ABHD6
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:1165, http://www.uniprot.org/uniprot/Q9Y4D2 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:28923, http://www.uniprot.org/uniprot/Q8NCG7 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:17038, http://www.uniprot.org/uniprot/Q99685 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:21398, http://www.uniprot.org/uniprot/Q9BV23 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:15868, http://www.uniprot.org/uniprot/Q8N2K0
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.‐ http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.‐ http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.23 http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.23 http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.23
Endogenous substrates diacylglycerol diacylglycerol http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5112 = http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=729http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2364 [http://www.ncbi.nlm.nih.gov/pubmed/15492019?dopt=AbstractPlus] 1‐arachidonoylglycerol > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=729 > 1‐oleoylglycerol > http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5112 [http://www.ncbi.nlm.nih.gov/pubmed/22969151?dopt=AbstractPlus]
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10246 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/26083464?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10244 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/26668358?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10243 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/26668358?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10245 (pIC50 5.6) [http://www.ncbi.nlm.nih.gov/pubmed/23103940?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10244 (pIC50 8.6) [http://www.ncbi.nlm.nih.gov/pubmed/26668358?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10243 (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/26668358?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10246 (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/26083464?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10245 (pIC50 7.1) [http://www.ncbi.nlm.nih.gov/pubmed/23103940?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10028 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/23731016?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9481 (pIC50 9.3) [http://www.ncbi.nlm.nih.gov/pubmed/23521796?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9482 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/22542104?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5207 (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/19029917?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5289 (pIC50 7.2) [http://www.ncbi.nlm.nih.gov/pubmed/17629278?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9480 (pIC50 6.4) [http://www.ncbi.nlm.nih.gov/pubmed/21084632?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10250 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/30720278?dopt=AbstractPlus]
Comments http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5289 has also been suggested to have activity at oxidative metabolic pathways independent of ABHD6 [http://www.ncbi.nlm.nih.gov/pubmed/28086912?dopt=AbstractPlus].