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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1375 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1376
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9604, http://www.uniprot.org/uniprot/P23219 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9605, http://www.uniprot.org/uniprot/P35354
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.99.1: Hydrogen donor + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391 + 2O2 = hydrogen acceptor + H2O + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4483 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391 => http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5245 => http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4483 This enzyme is also associated with the following reaction:: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1051 => PGH3 http://www.genome.jp/dbget‐bin/www_bget?ec:1.14.99.1: Hydrogen donor + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391 + 2O2 = hydrogen acceptor + H2O + http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4483 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2391 => http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5245 => http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4483 This enzyme is also associated with the following reaction:: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1051 => PGH3
Selective activators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10242 (Inhibition) (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/9135032?dopt=AbstractPlus]
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7131 (pIC50 8.1) [22], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2714 (pIC50 7.9) [http://www.ncbi.nlm.nih.gov/pubmed/16252917?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7219 (pIC50 7.3) [http://www.ncbi.nlm.nih.gov/pubmed/11844663?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4194 (pIC50 7.1) [http://www.ncbi.nlm.nih.gov/pubmed/10377455?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4820 (pIC50 6.8) [22], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4795 (pIC50 6.5) [http://www.ncbi.nlm.nih.gov/pubmed/18667313?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7298 (pIC50 6.2) [http://www.ncbi.nlm.nih.gov/pubmed/18667313?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7124 (pIC50 8.3) [22], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4194 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/10091674?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7219 (pIC50 7.4) [http://www.ncbi.nlm.nih.gov/pubmed/11844663?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7141 (pIC50 7) [http://www.ncbi.nlm.nih.gov/pubmed/21873070?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6661 (pIC50 6.9) [http://www.ncbi.nlm.nih.gov/pubmed/22091869?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7401 (pIC50 6.2) [http://www.ncbi.nlm.nih.gov/pubmed/15993594?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4795 (pIC50 6.2) [http://www.ncbi.nlm.nih.gov/pubmed/18667313?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6661 (pIC50 9.7) [http://www.ncbi.nlm.nih.gov/pubmed/10377455?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10241 (pIC50 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/21745460?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10240 (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/9789085?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5191 (pIC50 7.5) [http://www.ncbi.nlm.nih.gov/pubmed/10720634?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2892 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/12643942?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2894 (pIC50 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/10715145?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2714 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/17341061?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2893 (pIC50 6.1–6.5) [http://www.ncbi.nlm.nih.gov/pubmed/10377455?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2897 (pK i 6.5) [http://www.ncbi.nlm.nih.gov/pubmed/17434872?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7220 (pIC50 6.3) [http://www.ncbi.nlm.nih.gov/pubmed/9083488?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2896 (pIC50 6) [http://www.ncbi.nlm.nih.gov/pubmed/11160644?dopt=AbstractPlus]