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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1272 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1273
Common abbreviation GAD1 GAD2
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:4092, http://www.uniprot.org/uniprot/Q99259 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:4093, http://www.uniprot.org/uniprot/Q05329
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.15: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369 + H+ ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1067 + CO2 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.15: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369 + H+ ‐> http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1067 + CO2
Endogenous substrates http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3309 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3309
Products http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1067 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1067
Cofactors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5249
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5267 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5267
Comments http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3309 is a less rapidly metabolised substrate of mouse brain glutamic acid decarboxylase generating ß‐alanine [http://www.ncbi.nlm.nih.gov/pubmed/4700449?dopt=AbstractPlus]. Autoantibodies against GAD1 and GAD2 are elevated in type 1 diabetes mellitus and neurological disorders (see Further reading).