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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2153 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2154
Common abbreviation PI3Kα PI3Kß
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8975, http://www.uniprot.org/uniprot/P42336 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8976, http://www.uniprot.org/uniprot/P42338
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.1.153 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.11.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.1.153
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8012 (pIC50 9.5) [http://www.ncbi.nlm.nih.gov/pubmed/17601739?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7940 (pIC50 9.4) [http://www.ncbi.nlm.nih.gov/pubmed/20166697?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7936 (pK i 9.2) [http://www.ncbi.nlm.nih.gov/pubmed/24900269?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5701 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/19584227?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7951 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/22357447?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8011 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/23855836?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7950 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/18606717?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7888 (pIC50 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/21981714?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8012 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/16647110?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8011 (pIC50 9.3) [http://www.ncbi.nlm.nih.gov/pubmed/23855836?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5701 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/19584227?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8059 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/22906130?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7965 (pIC50 7.4–7.8) [665, http://www.ncbi.nlm.nih.gov/pubmed/16622124?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7888 (pIC50 7.6) [http://www.ncbi.nlm.nih.gov/pubmed/21981714?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7951 (pIC50 7.2) [http://www.ncbi.nlm.nih.gov/pubmed/22357447?dopt=AbstractPlus]
Sub/family‐selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5682 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/18754654?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5682 (pIC50 7.5) [http://www.ncbi.nlm.nih.gov/pubmed/18754654?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9826 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/24900173?dopt=AbstractPlus]