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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2156 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155
Common abbreviation PI3Kγ PI3Kδ
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8978, http://www.uniprot.org/uniprot/P48736 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8977, http://www.uniprot.org/uniprot/O00329
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.1.153 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.1.153
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7950 (pIC50 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/18606717?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7888 (pIC50 7.8) [http://www.ncbi.nlm.nih.gov/pubmed/21981714?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5701 (pIC50 7.8) [http://www.ncbi.nlm.nih.gov/pubmed/19584227?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7951 (pIC50 7.4) [http://www.ncbi.nlm.nih.gov/pubmed/22357447?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7965 (pIC50 7.3–7.3) [665, http://www.ncbi.nlm.nih.gov/pubmed/16622124?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5715 (pIC50 7.1) [http://www.ncbi.nlm.nih.gov/pubmed/17685602?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7955 (pIC50 6.6) [http://www.ncbi.nlm.nih.gov/pubmed/23726034?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8011 (pIC50 6.2) [http://www.ncbi.nlm.nih.gov/pubmed/23855836?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8011 (pIC50 > 10) [http://www.ncbi.nlm.nih.gov/pubmed/23855836?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6741 (in vitro activity against recombinant enzyme) (pIC50 8.6) [http://www.ncbi.nlm.nih.gov/pubmed/20959606?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5701 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/19584227?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7965 (pIC50 8.2–8.3) [665, http://www.ncbi.nlm.nih.gov/pubmed/16622124?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7888 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/21981714?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7950 (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/18606717?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7955 (pIC50 6.5) [http://www.ncbi.nlm.nih.gov/pubmed/23726034?dopt=AbstractPlus]
Sub/family‐selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5682 (pIC50 7.1) [http://www.ncbi.nlm.nih.gov/pubmed/18754654?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5682 (pIC50 8.5) [http://www.ncbi.nlm.nih.gov/pubmed/18754654?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6653 (pIC50 7.6) [http://www.ncbi.nlm.nih.gov/pubmed/22544264?dopt=AbstractPlus]