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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1503 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1504
Systematic nomenclature ROCK1 ROCK2
Common abbreviation Rho kinase 1 Rho kinase 2
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:10251, http://www.uniprot.org/uniprot/Q13464 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:10252, http://www.uniprot.org/uniprot/O75116
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.11.1 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.11.1
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8152 (pIC50 >9) [http://www.ncbi.nlm.nih.gov/pubmed/23275831?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5290 (pIC50 5.9–7.3) [http://www.ncbi.nlm.nih.gov/pubmed/19597037?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/20462760?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5181 (pK i 7) [http://www.ncbi.nlm.nih.gov/pubmed/21145740?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5290 (pK i 6.8) [http://www.ncbi.nlm.nih.gov/pubmed/9353125?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5181 (pIC50 5.5–5.6) [http://www.ncbi.nlm.nih.gov/pubmed/19597037?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/21145740?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8152 (pIC50 >9) [http://www.ncbi.nlm.nih.gov/pubmed/23275831?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8197 (pIC50 >9) [95], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8037 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/17018693?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8184 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/20471253?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8205 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/20462760?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5290 (pIC50 6.3–7.2) [http://www.ncbi.nlm.nih.gov/pubmed/19597037?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/20462760?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5290 (pK i 6.8–6.9) [http://www.ncbi.nlm.nih.gov/pubmed/19597037?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/9353125?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5181 (pIC50 5.9–5.9) [http://www.ncbi.nlm.nih.gov/pubmed/19597037?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/21145740?dopt=AbstractPlus]
Selective inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8037 (pIC50 8.8) [http://www.ncbi.nlm.nih.gov/pubmed/17018693?dopt=AbstractPlus]