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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1262 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1263 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1265 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1268
Common abbreviation PC ACC1 ACC2 PCCA,PCCB GGCX
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:8636, http://www.uniprot.org/uniprot/P11498 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:84, http://www.uniprot.org/uniprot/Q13085 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:85, http://www.uniprot.org/uniprot/O00763 – https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:4247, http://www.uniprot.org/uniprot/P38435
Subunits – – – http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1267, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1266 –
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:6.4.1.1 http://www.genome.jp/dbget‐bin/www_bget?ec:6.4.1.2 http://www.genome.jp/dbget‐bin/www_bget?ec:6.4.1.2 http://www.genome.jp/dbget‐bin/www_bget?ec:6.4.1.3 http://www.genome.jp/dbget‐bin/www_bget?ec:4.1.1.90
Endogenous substrates http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1713, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4809 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1713, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3038 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3038, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1713 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5248, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1713 glutamyl peptides
Products Pi, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1712, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5236 Pi, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1712, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5219 Pi, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1712, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5219 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1712, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5223, Pi carboxyglutamyl peptides
Cofactors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4787 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4787 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4787 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4787 http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5286, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3041
Inhibitors – – – – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6960
Selective inhibitors – http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8884 (pIC50 8) [http://www.ncbi.nlm.nih.gov/pubmed/23981033?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5280 (pIC50 4.9) [http://www.ncbi.nlm.nih.gov/pubmed/14612531?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8884 (pIC50 8.4) [http://www.ncbi.nlm.nih.gov/pubmed/23981033?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5280 (pIC50 4.9) [http://www.ncbi.nlm.nih.gov/pubmed/14612531?dopt=AbstractPlus] – –
Comments – Citrate and other dicarboxylic acids are allosteric activators of acetyl‐CoA carboxylase. Citrate and other dicarboxylic acids are allosteric activators of acetyl‐CoA carboxylase. Propionyl‐CoA carboxylase is able to function in both forward and reverse activity modes, as a ligase (carboxylase) or lyase (decarboxylase), respectively. Loss‐of‐function mutations in γ‐glutamyl carboxylase are associated with http://omim.org/entry/277450.