Nomenclature	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2030
Common abbreviation	GSK3B
HGNC, UniProt	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:4617, http://www.uniprot.org/uniprot/P49841
EC number	http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.11.26
Inhibitors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8016 (pIC50 9.2) [http://www.ncbi.nlm.nih.gov/pubmed/12606497?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7958 (pIC50 9) [http://www.ncbi.nlm.nih.gov/pubmed/15267232?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8014 (pIC50 8.2) [http://www.ncbi.nlm.nih.gov/pubmed/12606497?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8015 (pIC50 ~8.1) [http://www.ncbi.nlm.nih.gov/pubmed/11033082?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8018 (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/14698171?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8019 (pIC50 ~7.4) [http://www.ncbi.nlm.nih.gov/pubmed/11033082?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8017 (pIC50 7.3) [http://www.ncbi.nlm.nih.gov/pubmed/20708937?dopt=AbstractPlus]
Selective inhibitors	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8478 (pK i 8.3) [http://www.ncbi.nlm.nih.gov/pubmed/22489897?dopt=AbstractPlus]
Comments	Due to its Tau phosphorylating activity, small molecule inhibitors of GSK‐3β are being investigated as potential treatments for Alzheimer's disease (AD) [http://www.ncbi.nlm.nih.gov/pubmed/22489897?dopt=AbstractPlus]. GSK‐3β also plays a role in canonical Wnt pathway signalling, the normal activity of which is crucial for the maintenance of normal bone mass. It is hypothesised that small molecule inhibitors of GSK‐3β may provide effective therapeutics for the treatment of diseases characterised by low bone mass [http://www.ncbi.nlm.nih.gov/pubmed/22142634?dopt=AbstractPlus].