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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2062 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2063
Common abbreviation MEK1 MEK2
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6840, http://www.uniprot.org/uniprot/Q02750 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:6842, http://www.uniprot.org/uniprot/P36507
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.12.2 http://www.genome.jp/dbget‐bin/www_bget?ec:2.7.12.2
Inhibitors http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6495 (pIC50 9–9.1) [http://www.ncbi.nlm.nih.gov/pubmed/21245089?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/21523318?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7935 (pIC50 8.1) [http://www.ncbi.nlm.nih.gov/pubmed/23474388?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6495 (pIC50 8.7) [http://www.ncbi.nlm.nih.gov/pubmed/21523318?dopt=AbstractPlus]
Allosteric modulators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7921 (Negative) (pIC50 7.9) [468], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7942 (Negative) (pIC50 7.7) [http://www.ncbi.nlm.nih.gov/pubmed/19706763?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5676 (Negative) (pK d 6.9) [http://www.ncbi.nlm.nih.gov/pubmed/22037378?dopt=AbstractPlus] http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7921 (Negative) (pIC50 7.9) [468], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7942 (Negative) (pIC50 7.3) [http://www.ncbi.nlm.nih.gov/pubmed/19706763?dopt=AbstractPlus]
Selective allosteric modulators http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7626 (Negative) (pIC50 9.1) [500]