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. 2019 Nov 11;176(Suppl 1):S297–S396. doi: 10.1111/bph.14752
Nomenclature http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3052 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3053 http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3054
Common abbreviation PON1 PON2 PON3
HGNC, UniProt https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9204, http://www.uniprot.org/uniprot/P27169 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9205, http://www.uniprot.org/uniprot/Q15165 https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:9206, http://www.uniprot.org/uniprot/Q15166
EC number http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.8.1 An aryl dialkyl phosphate + H(2)O <=> dialkyl phosphate + an aryl alcohol http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.2 A phenyl acetate + H(2)O <=> a phenol + acetate http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.81 An N‐acyl‐L‐homoserine lactone + H(2)O <=> an N‐acyl‐L‐homoserine http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.2 A phenyl acetate + H(2)O <=> a phenol + acetate http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.81 A N‐acyl‐L‐homoserine lactone + H(2)O <=> a N‐acyl‐L‐homoserine http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.8.1 An aryl dialkyl phosphate + H(2)O <=> dialkyl phosphate + an aryl alcohol http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.2 A phenyl acetate + H(2)O <=> a phenol + acetate http://www.genome.jp/dbget‐bin/www_bget?ec:3.1.1.81 A N‐acyl‐L‐homoserine lactone + H(2)O <=> a N‐acyl‐L‐homoserine
Comments PON1 forms homodimers. Loss‐of‐function mutations in PON1 are associated with microvascular complications of diabetes [http://www.ncbi.nlm.nih.gov/pubmed/11918623?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/9661650?dopt=AbstractPlus]. PON2 forms heterotrimers [http://www.ncbi.nlm.nih.gov/pubmed/15772423?dopt=AbstractPlus]. PON3 likely forms heterodimers in vivo [http://www.ncbi.nlm.nih.gov/pubmed/15772423?dopt=AbstractPlus].