Nomenclature	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=388	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=389	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=390	http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=391
HGNC, UniProt	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:17116, http://www.uniprot.org/uniprot/Q8NEC5	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:18810, http://www.uniprot.org/uniprot/Q96P56	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:20819, http://www.uniprot.org/uniprot/Q86XQ3	https://www.genenames.org/data/gene‐symbol‐report/#!/hgnc_id/HGNC:23220, http://www.uniprot.org/uniprot/Q7RTX7
Activators	CatSper1 is constitutively active, weakly facilitated by membrane depolarisation, strongly augmented by intracellular alkalinisation. In human, but not mouse, progesterone (EC50 8 nM) also potentiates the CatSper current (ICatSper). [http://www.ncbi.nlm.nih.gov/pubmed/21412339?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/21412338?dopt=AbstractPlus]	–	–	–
Channel blockers	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2432 (Inhibition) (pIC50 5) [http://www.ncbi.nlm.nih.gov/pubmed/16467839?dopt=AbstractPlus] – Mouse, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4212 (pIC50 4.7) [http://www.ncbi.nlm.nih.gov/pubmed/19718436?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2440 (Inhibition) (pIC50 3.7) [http://www.ncbi.nlm.nih.gov/pubmed/16467839?dopt=AbstractPlus] – Mouse, http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2476 (Inhibition) (pIC50 3.5) [http://www.ncbi.nlm.nih.gov/pubmed/16467839?dopt=AbstractPlus] – Mouse	–	–	–
Selective channel blockers	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4269 (Inhibition) (pIC50 5.7) [−80mV – 80mV] [http://www.ncbi.nlm.nih.gov/pubmed/21412339?dopt=AbstractPlus, http://www.ncbi.nlm.nih.gov/pubmed/21412338?dopt=AbstractPlus], http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2522 (Inhibition) (pIC50 4.4–4.5) [http://www.ncbi.nlm.nih.gov/pubmed/21412338?dopt=AbstractPlus]	–	–	–
Functional Characteristics	Calcium selective ion channel (Ba2+>Ca2+Mg2+Na+); quasilinear monovalent cation current in the absence of extracellular divalent cations; alkalinization shifts the voltage‐dependence of activation towards negative potentials [V @ pH 6.0 = +87 mV (mouse); V @ pH 7.5 = +11mV (mouse) or pH 7.4 = +85 mV (human)]; required for ICatSper and male fertility (mouse and human)	Required for ICatSper and male fertility (mouse and human)	Required for ICatSper and male fertility (mouse)	Required for ICatSper and male fertility (mouse)